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In the second part of our conversation on AI, machine learning, and computer-aided diagnosis, we are joined by David Louis, MD, the Benjamin Castleman Professor of Pathology at HMS; chair of the Executive Committee on Research at MGH; and chair of the department of Pathology at MGH. Under his chairmanship, MGH Pathology has become a national leader in molecular diagnostics and pathology informatics, leading to a novel initiative in computational pathology. In this episode, Dr. Louis discusses how pathology has approached computer-aided diagnosis, how pathologists are confronting the fears and challenges of potential AI implementations and his outlook for an exciting future in diagnostic medicine.