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To watch this episode, please visit Rachel’s YouTube channel. Listeners can find Dr. Dominic D’Agostino at his website https://www.ketonutrition.org/, Twitter @DominicDAgosti2, on Facebook @Dominic D’Agostino and on Instagram dominic.dagostino.kt. Dr. Dominic D’Agostino is an Associate Professor in the Department of Molecular Pharmacology and Physiology at the University of South Florida and Research Scientist at the Institute for Human and Machine Cognition (IHMC). His laboratory develops and tests metabolic-based strategies for neurological disorders, cancer, and for enhancing safety and resilience of military personnel in extreme environments. His research is supported by the Office of Naval Research (ONR), Department of Defense (DoD), private organizations and foundations. In this episode, we chat all about exogenous ketones, ‘the keto diet vs. the drink,’ fuel supplementation for performance, benefits of a higher protein ketogenic approach, and more! "I have changed my mind pretty significantly through self experimentation. But even from a clinical research realm, you can incorporate a higher protein macronutrient ratio, and still be following a ketogenic diet by definition of having elevated ketones." Dr. Dominic D'Agostino "A lot of people think keto is so restrictive. But if you use it in smart ways and you incorporate it into the different seasons of your life, it can be super beneficial, and you can still kind of get the best of both worlds." Rachel Gregory Top Takeaways: A breakdown of what ketones are and some benefits  How to spot the best exogenous ketones The difference between Ketone Salts vs. Ketone Esters Ketones and carbs for performance The benefits of a higher protein ketogenic diet Today’s Questions: What are the positive effects of ketones as signaling molecules, in simple terms? Is there more research coming out in humans with ketogenic diets and exogenous ketones? What are the best exogenous ketones? What is your opinion on taking exogenous ketones and not following a ketogenic diet vs. following a ketogenic diet and also incorporating exogenous ketones? What's your view on the concept of metabolic flexibility? Are there negatives to taking exogenous ketones? What’s the difference between ketone salts and ketone esters? What’s your personal diet and training protocol like? Show Notes: [0:00] Welcome back to MetFlex and Chill! Rachel gives a brief background about guest Dr. Dominic D’Agostino dominic.dagostino.kt [2:00] If you are enjoying the show please like, tag @rachelgregory.cns and share! Another way to help spread the word is to share a review on itunes!   [2:30] Rachel introduces guest Dr. Dominic D’Agostino to the listeners [3:30] Dr. Agostino gives a brief bio on how he got into nutrition and specifically ketogenic diets [4:30] Oxygen Toxicity Seizures  [8:30] Question: What are the positive effects of ketones as signaling molecules, in simple terms? [11:00] GABA [13:30] Ketones also have epigenetic effects [18:00] Glucose Transporter Deficiency Syndrome (GLUT 1 Deficiency Syndrome) [19:00] Dr. Richard Veech [21:00] Rachel’s CrossFit Study [22:00] Question: Is there more research coming out in humans with ketogenic diets and exogenous ketones? Can you speak to that versus animal research? [23:00] clinicaltrials.gov  [27:00] Question: What are the best exogenous ketones? [28:00] Ketone Supplements [29:00] How to Choose an Exogenous Ketone Supplement [29:30] Question: What is your opinion on taking exogenous ketones and not following a ketogenic diet vs. following a ketogenic diet and also incorporating exogenous ketones? [38:30] Question: What's your view on the concept of metabolic flexibility? [38:30] Episode 21: The Science of Metabolic Flexibility with Dr. Mike T Nelson [45:30] Question: Are there negatives to taking exogenous ketones? [48:30] Question: What’s the difference between ketone salts and ketone esters? [52:30] Question: Dr. Dom’s personal diet and training protocol? [59:00] Question: Anything you’ve changed your mind about in the past year and why? [1:03:00] You can find Dr. Dominic D’Agostino at https://www.ketonutrition.org/ and on Instagram dominic.dagostino.kt [1:03:00] Thanks for listening to another episode! If you are curious about Dr. D’Agostino’s work check it out at https://www.ketonutrition.org/  If you are enjoying the show please like, tag @rachelgregory.cns and share!   --- Join the FREE MetFLex Life Course: www.metflexandchill.com Rachel Gregory (@rachelgregory.cns) is a Board-Certified Nutrition Specialist, Strength and Conditioning Specialist, and Author of the best-selling book, 21-Day Ketogenic Diet Weight Loss Challenge. She received her Master’s Degree in Nutrition a Exercise Physiology from James Madison University and Bachelor’s Degree in Sports Medicine from the University of Miami. Rachel helps her clients transform their lives by starting with the physical (body), realizing the power of the mental (mindset), and ultimately gaining massive confidence that bleeds into every aspect of their lives (family, relationships, work, etc.).