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Here is a summary of this episode: Always ask about over-the-counter drugs like antacids, antiemetics, and spasmolytics as they may interfere with drug absorption. In patients who have undergone gastric bypass, use immediate release formulations, or give liquid form of drugs. There is evidence to suggest that IBS-constipation responds better to SSRIs and IBS-diarrhea to TCAs. The risk of GIT bleeding with SSRIs is 1.5 to 2 times greater. Patients with a defect in platelet number or function and those who H. pylori infection are at greater risk. Download a PDF of this interview here Become a premium member of the Psychopharmacology Institute