lystn

Part two of CRISPR and genetic editing! This time, we talk about what plants and animals we have already CRISPR'd! Also, we discuss CRISPRs in the context of human health. Then, at the insistence of Nathan and Andrei, Sean is forced to discuss the ethical conundrums that come up surrounding the democratization of genetic modification. Nathan starts this episode out with a trigger warning about GMOs, but a less facetious trigger warning for this episode is that we discuss CRISPR and genetic modifications in the context of bioterrorism later in the episode (48:30-55:10), so if for whatever reason you find such things hard to listen to, you know which chunk to skip!Sean mentions silkworms as an organism that has been successfully CRISPR'd, but missed a paper that wasn't just proof of concept -- they shoved in spider silk genes and make a hybrid silk, which is super cool! Stuff is getting CRISPR'd all the time, and new forms of CRISPR are getting engineered in labs all over the world, so this episode is pretty much immediately out of date, but whatever, whaddya gonna do.If you have a gene you want to CRISPR, or want to yell at us for misrepresenting something, tweet us @dishpodcast or email us at petridishpod at gmail.com! Check us out on patreon.com/petridish for early release of episodes and some other kinds of stuff.References:https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0177966https://onlinelibrary.wiley.com/doi/full/10.1111/pbi.12832https://onlinelibrary.wiley.com/doi/full/10.1111/pbi.12927https://onlinelibrary.wiley.com/doi/full/10.1111/jipb.12620https://www.nature.com/articles/s41598-018-34104-4http://www.plantphysiol.org/content/174/2/935.fullhttps://www.sciencedirect.com/science/article/pii/S1359511316309047https://www.nature.com/articles/cr2013146https://science.sciencemag.org/content/357/6357/1303.abstracthttps://www.sciencedirect.com/science/article/pii/S0965174816301394https://genomebiology.biomedcentral.com/articles/10.1186/s13059-016-1144-4#Sec1https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0106718#abstract0https://www.nature.com/articles/srep13878https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6643211/https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0108622https://www.nature.com/articles/nbt.3439https://www.nature.com/articles/nbt.3473https://www.embopress.org/doi/full/10.15252/embj.201899243https://www.nature.com/articles/cr20189https://www.cell.com/molecular-therapy-family/molecular-therapy/pdfExtended/S1525-0016(16)45428-6https://synbiobeta.com/crispr-clinical-trials-a-2019-update/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6414166/https://academic.oup.com/jlb/article/3/2/413/1751234#98305641https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6058482/https://www.nature.com/articles/s41467-018-05843-9https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4779287/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4278802/https://www.nature.com/articles/s41580-019-0131-5https://www.nature.com/articles/s41592-019-0508-6https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3145266/